Minagawa T, Hirano T, Takada N, Ishiguro M, Ohtsuka H
Hirano General Hospital Cardiovascular Division, Gifu, Japan.
Nihon Jinzo Gakkai Shi. 1994 Aug;36(8):934-41.
The purpose of this study was to examine the effect of recombinant human erythropoietin (r-HuEPO) on left ventricular mass. Twenty-seven hemodialysis patients (13 men and 14 women) were given r-HuEPO for renal anemia. Blood pressure and heart rate were measured before and after the 16-week course of r-HuEPO, and at the same time echocardiography was performed to measure left ventricular dimensions and wall thickness. These measurements were used to calculate left ventricular volume, cardiac output (CO), and left ventricular mass (LVmass). Diastolic blood pressure (DBP) increased after administration of r-HuEPO (from 75.8 +/- 10.8 mmHg to 85.6 +/- 12.7 mmHg), but there was no change in systolic blood pressure (SBP) or heart rate. LVmass increased significantly in seven cases (from 194.7 +/- 40.0 g to 240.3 +/- 47.3 g). These cases, Group I, showed no decline in stroke volume (SV) or CO, and showed significant increases in SBP. In the remaining 20 cases, Group II, LVmass decreased or was unchanged. In this group SV and CO decreased, but there was no increase in SBP. We conclude that increases in LVmass may be associated with elevated systolic blood pressure and hypertrophy of the left ventricular wall, when hemodialysis patients with severe renal anemia are given r-HuEPO.
本研究的目的是探讨重组人促红细胞生成素（r-HuEPO）对左心室质量的影响。27例血液透析患者（13例男性和14例女性）因肾性贫血接受r-HuEPO治疗。在16周的r-HuEPO疗程前后测量血压和心率，同时进行超声心动图检查以测量左心室尺寸和壁厚度。这些测量值用于计算左心室容积、心输出量（CO）和左心室质量（LVmass）。给予r-HuEPO后舒张压（DBP）升高（从75.8±10.8 mmHg升至85.6±12.7 mmHg），但收缩压（SBP）或心率无变化。7例患者（I组）的LVmass显著增加（从194.7±40.0 g增至240.3±47.3 g）。这些病例的每搏输出量（SV）或CO没有下降，SBP显著升高。其余20例患者（II组）的LVmass下降或无变化。该组的SV和CO下降，但SBP没有升高。我们得出结论，当严重肾性贫血的血液透析患者接受r-HuEPO治疗时，LVmass增加可能与收缩压升高和左心室壁肥厚有关。
