Hazel S J, Gillespie C M, Moore R J, Clark R G, Jureidini K F, Martin A A
Cooperative Research Centre for Tissue Growth and Repair, Child Health Research Institute, North Adelaide, Australia.
Kidney Int. 1994 Jul;46(1):58-68. doi: 10.1038/ki.1994.244.
The efficacy of seven days treatment with IGF-I (1.7 mg/kg/day), growth hormone (GH) (2 mg/kg/day), IGF-I+GH (1.7 mg/kg/day + 2 mg/kg/day) or vehicle, in promoting growth was investigated in female Sprague-Dawley rats with 5/6 nephrectomies (N = 8 per group). Treatment commenced after chronic renal failure had been present for seven weeks. Significant increases in body weight gain were found in all groups versus control, with IGF-I+GH causing the greatest response, and increased body weight gains correlating with increased nitrogen retention. GH treatment alone significantly stimulated food intake. IGF-I+GH resulted in close to additive increases in food conversion efficiency (18.8%, 21.5% and 39.6% increases with IGF-I, GH and IGF-I+GH, respectively, over control levels) and longitudinal bone growth (39%, 37% and 67% increases with IGF-I, GH and IGF-I+GH, respectively, vs. control). Serum insulin and cholesterol levels significantly decreased with IGF-I and IGF-I+GH treatment. Creatinine clearance did not change, suggesting there were no effects of treatment on kidney function. Although IGF-I at the doses used did not result in a greater anabolic response than GH, IGF-I+GH caused significantly enhanced growth while reducing serum insulin and cholesterol levels.
在接受5/6肾切除的雌性Sprague-Dawley大鼠（每组N = 8只）中，研究了用胰岛素样生长因子-I（IGF-I，1.7毫克/千克/天）、生长激素（GH，2毫克/千克/天）、IGF-I + GH（1.7毫克/千克/天 + 2毫克/千克/天）或赋形剂进行为期七天的治疗对促进生长的效果。治疗在慢性肾衰竭出现七周后开始。与对照组相比，所有组的体重增加均显著增加，其中IGF-I + GH引起的反应最大，体重增加与氮潴留增加相关。单独使用GH治疗显著刺激食物摄入量。IGF-I + GH导致食物转化效率接近相加性增加（与对照组相比，IGF-I、GH和IGF-I + GH分别增加18.8%、21.5%和39.6%）以及纵向骨生长增加（与对照组相比，IGF-I、GH和IGF-I + GH分别增加39%、37%和67%）。IGF-I和IGF-I + GH治疗后血清胰岛素和胆固醇水平显著降低。肌酐清除率没有变化，表明治疗对肾功能没有影响。尽管所用剂量的IGF-I没有比GH产生更大的合成代谢反应，但IGF-I + GH在降低血清胰岛素和胆固醇水平的同时显著增强了生长。
