Meyer N A, Barrow R E, Herndon D N
Shriners Burn Institute, Galveston, TX 77550, USA.
J Trauma. 1996 Dec;41(6):1008-12. doi: 10.1097/00005373-199612000-00011.
The anabolic effects of growth hormone (GH) in burned patients appear to act both directly and through insulin-like growth factor-1 (IGF-1). We, therefore, hypothesize that exogenous GH plus IGF-1 will attenuate increases in metabolism and lean muscle wasting while promoting wound healing.
Rats, each weighing 440-470 g, were given a 35% total body surface area, full-thickness scald burn and divided into four groups to receive placebo (burned controls), bovine GH (2.5 mg/kg/day), IGF-1 (2.0 mg/kg/day), or bovine GH plus rhIGF-1 (2.5 + 2.0 mg/kg/day), respectively, for 8 weeks.
Total body weight gain after 8 weeks averaged 110 g for GH plus IGF-1 compared with gains of 49 and 11 g for GH or IGF-1 alone, respectively. Burned controls lost 24 g. Metabolic rates were significantly reduced in all groups receiving growth hormones. Gastrocnemius muscle dry weight was significantly increased in those receiving GH plus IGF-1 compared with GH and IGF-1 alone or burned controls (p < .01).
Data show that GH plus IGF-1 synergistically increased lean muscle weight, total body weight, and was more effective in re-epithelialization of the burn wound than either GH or IGF-1 alone.
生长激素（GH）对烧伤患者的合成代谢作用似乎是直接发挥的，并且是通过胰岛素样生长因子-1（IGF-1）发挥作用。因此，我们假设外源性GH加IGF-1将减轻代谢增加和瘦肌肉消耗，同时促进伤口愈合。
将体重440 - 470克的大鼠进行35%体表面积的全层烫伤，分为四组，分别接受安慰剂（烧伤对照组）、牛GH（2.5毫克/千克/天）、IGF-1（2.0毫克/千克/天）或牛GH加重组人IGF-1（2.5 + 2.0毫克/千克/天），持续8周。
8周后，GH加IGF-1组的总体重平均增加110克，而单独使用GH或IGF-1组的体重增加分别为49克和11克。烧伤对照组体重减轻24克。所有接受生长激素的组代谢率均显著降低。与单独使用GH、IGF-1或烧伤对照组相比，接受GH加IGF-1的组腓肠肌干重显著增加（p <.01）。
数据表明，GH加IGF-1协同增加瘦肌肉重量和总体重，并且在烧伤创面再上皮化方面比单独使用GH或IGF-1更有效。
