Bolton W K, Benton F R, Maclay J G, Sturgill B C
Am J Pathol. 1976 Nov;85(2):277-302.
The present studies examined the pathogenesis of focal glomerular sclerosis in aging rats. A marked difference in development of the lesion was noted between males and females, and strain variability was an important factor. Increased glomerular basement membrane permeability with loss of selectivity unrelated to changes in glomerular sialoprotein occurred with aging and was accompanied by increasing proteinuria. Noncomplement-fixing mesangial deposits of rat IgM were present after 1 month of age and were also found in lesser amounts in germfree rats. Fluoresceinated eluates of rat kidneys did not have antibody activity against rat serum or tissue antigens. There was no evidence for a pathogenetic role of IgM deposits. Rat IgG, IgA, IgE, C3, and fibrin were occasionally found in sclerotic areas. Analysis of multiple histologic sections revealed a close correlation between aging and glomerular pathology, with a poor correlation between tubular damage and aging. Glomerular damage appeared to be the initial event leading to tubular damage. Indirect evidence suggests that a relative thymic deficiency may play an important role in the pathogenesis of the lesion.
目前的研究探讨了衰老大鼠局灶性肾小球硬化的发病机制。研究发现，雄性和雌性大鼠在病变发展上存在显著差异，品系变异性是一个重要因素。随着年龄增长，肾小球基底膜通透性增加，选择性丧失，这与肾小球涎蛋白的变化无关，并伴有蛋白尿增加。1月龄后出现大鼠IgM的非补体结合系膜沉积物，无菌大鼠中也有少量发现。大鼠肾脏的荧光洗脱物没有针对大鼠血清或组织抗原的抗体活性。没有证据表明IgM沉积物具有致病作用。硬化区域偶尔会发现大鼠IgG、IgA、IgE、C3和纤维蛋白。对多个组织学切片的分析显示，衰老与肾小球病理密切相关，而肾小管损伤与衰老之间的相关性较差。肾小球损伤似乎是导致肾小管损伤的初始事件。间接证据表明，相对胸腺功能不足可能在病变的发病机制中起重要作用。
