Elema J D, Arends A
Lab Invest. 1975 Nov;33(5):554-61.
A glomerular disease spontaneously developing in Wistar rats was studied by light and electron microscopy and by immunofluorescence techniques. The disease is characterized by the local subendothelial deposition of hyaline material leading to increase of mesangial matrix and the development of adhesions. Immunofluorescence shows deposition of complement and IgM and to a lesser degree also of IgG in these lesions. There is a constant relationship of these early changes with the vascular pole of the glomerulus. It is confirmed that female rats are resistent to the disease as are male rats fed a sodium-deficient diet. A higher protein excretion was found in normally fed male rats as compared to female rats and to rats on a sodium-deficient diet. These differences already existed before the normally fed male rats developed glomerular disease. From these studies it is suggested that an appropriate name for this disease would be focal and segmental glomerular hyalinosis and sclerosis and that hemodynamic factors could be an important etiologic mechanism. The histopathology of the disease bears a striking resemblance to focal sclerosing glomerulopathy with segmental hyalinosis sometimes found in kidneys of patients with an idiopathic nephrotic syndrome.
通过光学显微镜、电子显微镜以及免疫荧光技术对Wistar大鼠自发发生的一种肾小球疾病进行了研究。该疾病的特征是透明物质在局部内皮下沉积，导致系膜基质增加和粘连形成。免疫荧光显示补体和IgM在这些病变中沉积，IgG的沉积程度较轻。这些早期变化与肾小球血管极存在恒定关系。已证实雌性大鼠对该疾病具有抵抗力，喂食缺钠饮食的雄性大鼠也如此。与雌性大鼠和喂食缺钠饮食的大鼠相比，正常喂食的雄性大鼠蛋白质排泄量更高。这些差异在正常喂食的雄性大鼠发生肾小球疾病之前就已存在。从这些研究中可以看出，这种疾病合适的名称可能是局灶节段性肾小球玻璃样变和硬化，并且血流动力学因素可能是一个重要的病因机制。该疾病的组织病理学与特发性肾病综合征患者肾脏中有时发现的伴有节段性玻璃样变的局灶节段性肾小球硬化症极为相似。
