Becker G D, Adams L A, Hackett J
Department of Otolaryngology-Head and Neck Surgery, Southern California Permanente Medical Group, Panorama City, Calif.
Laryngoscope. 1994 Oct;104(10):1267-70. doi: 10.1288/00005537-199410000-00015.
Allowing selected full-thickness skin defects to heal by secondary intention offers the advantages of optimal cancer surveillance, simplified wound management, and avoidance of reconstructive procedures with their associated costs and potential complications. The topical use of bovine collagen has been suggested as a method of enhancing wound closure and final cosmetic appearance. This study evaluated the effect of bovine collagen on wound healing in patients undergoing facial Mohs surgery using the fresh-tissue technique. A total of 111 consecutive patients were assigned to a collagen or no-collagen group. Wound care was identical except for the weekly addition of bovine collagen to the wound of patients in the collagen group. Evaluation was at weekly intervals until the wound epithelialized, then bimonthly for at least 6 months. There was no difference in the rate of wound epithelialization or final cosmetic appearance. This study provides no evidence that the topical use of bovine collagen in a facial wound after Mohs surgery enhances wound epithelialization or the final cosmetic appearance.
最佳的癌症监测、简化的伤口管理，以及避免重建手术及其相关成本和潜在并发症。有人建议局部使用牛胶原蛋白作为一种促进伤口闭合和改善最终美容效果的方法。本研究使用新鲜组织技术评估了牛胶原蛋白对接受面部莫氏手术患者伤口愈合的影响。总共111例连续患者被分配到胶原蛋白组或无胶原蛋白组。除了每周在胶原蛋白组患者的伤口上添加牛胶原蛋白外，伤口护理相同。每周进行评估，直到伤口上皮化，然后每两个月评估一次，至少持续6个月。伤口上皮化率或最终美容效果没有差异。本研究没有提供证据表明在莫氏手术后的面部伤口局部使用牛胶原蛋白能促进伤口上皮化或改善最终美容效果。
