自磷酸化：蛋白激酶的一个显著特征。
Autophosphorylation: a salient feature of protein kinases.
作者信息
Smith J A, Francis S H, Corbin J D
机构信息
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615.
出版信息
Mol Cell Biochem. 1993 Nov;127-128:51-70. doi: 10.1007/BF01076757.
Most protein kinases catalyze autophosphorylation, a process which is generally intramolecular and is modulated by regulatory ligands. Either serine/threonine or tyrosine serves as the phosphoacceptor, and several sites on the same kinase subunit are usually autophosphorylated. Autophosphorylation affects the functional properties of most protein kinases. Members of the protein kinase family exhibit diversity in the characteristics and functions of autophosphorylation, but certain common themes are emerging.
大多数蛋白激酶催化自身磷酸化，这一过程通常是分子内的，并受调节性配体调控。磷酸化受体可以是丝氨酸/苏氨酸，也可以是酪氨酸，同一激酶亚基上的多个位点通常会发生自身磷酸化。自身磷酸化会影响大多数蛋白激酶的功能特性。蛋白激酶家族成员在自身磷酸化的特征和功能上表现出多样性，但一些共同的特点正在显现。
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