1982年至1991年期间，印度昌迪加尔及其周边地区隐球菌病的发病率。

Incidence of cryptococcosis in and around Chandigarh, India, during the period 1982-91.

作者信息

Chander J, Sapra R K, Talwar P

机构信息

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Mycoses. 1994 Jan-Feb;37(1-2):23-6. doi: 10.1111/j.1439-0507.1994.tb00280.x.

DOI:10.1111/j.1439-0507.1994.tb00280.x

PMID:7935587

Abstract

The incidence of cryptococcosis was evaluated in and around Chandigarh, India over a period of 10 years (1982-91). Different species of Cryptococcus were isolated from 38 patients. Cryptococcus neoformans was the predominant isolate (26 = 68%) followed by Cr. albidus (2), Cr. laurentii (1) and not precisely identified Cryptococcus species (9 = 24%). Serotyping of the 18 isolates of Cr. neoformans revealed that 13 (72%) were serotype A, two (11%) were serotype AD and three (17%) were serotype B (Cr. neoformans var. gattii). Cryptococcus species were found to produce infection in 24 patients and were possibly transient colonizers in another 14 patients. In addition, in 11 patients no Cryptococcus species was isolated from any site but the latex agglutination test for antigen (Crypto-LA) was positive in serum and/or cerebrospinal fluid. Response to various antifungal drugs was also studied in these patients.

摘要

在印度昌迪加尔及其周边地区，对10年期间（1982 - 1991年）隐球菌病的发病率进行了评估。从38例患者中分离出不同种类的隐球菌。新型隐球菌是主要的分离菌株（26株 = 68%），其次是浅白隐球菌（2株）、罗伦隐球菌（1株）以及未准确鉴定的隐球菌种类（9株 = 24%）。对18株新型隐球菌进行血清分型显示，13株（72%）为血清型A，2株（11%）为血清型AD，3株（17%）为血清型B（新型隐球菌变种格特隐球菌）。发现隐球菌种类在24例患者中引发感染，在另外14例患者中可能为短暂定植菌。此外，11例患者的任何部位均未分离出隐球菌种类，但血清和/或脑脊液中的抗原乳胶凝集试验（Crypto - LA）呈阳性。还对这些患者对抗各种抗真菌药物的反应进行了研究。