Mazur-Kolecka B, Machala O, Skowron-Cendrzak A, Kubera M, Bubak-Satora M, Basta-Kaim A, Roman A
Department of Immunology, Polish Academy of Sciences, Kraków.
Neoplasma. 1994;41(3):183-6.
The effect of immobilization stress applied daily for 2 h on the development of MF-RSV tumor graft in mice and on survival of the hosts was studied. While a single acute stress applied to mice simultaneously with a transfer of MF-RSV cells stimulated antitumor defense, chronic stress applied both before and/or after tumor cell implantation accelerated the death of recipients. The shortest survival time was found in mice which were stressed for 3 weeks before implantation and on, until their death. Heat shock applied to MF-RSV tumor cells before implantation significantly reduced their growth ability in the hosts.
研究了每天施加2小时固定应激对小鼠MF - RSV肿瘤移植瘤发展及宿主存活的影响。与MF - RSV细胞移植同时对小鼠施加单次急性应激可刺激抗肿瘤防御，而在肿瘤细胞植入前和/或后施加慢性应激则加速受体死亡。在植入前3周及之后一直处于应激状态直至死亡的小鼠中观察到最短存活时间。在植入前对MF - RSV肿瘤细胞施加热休克可显著降低其在宿主中的生长能力。
