de Blaquière G E, Santamaria L, Curtis J, Terenghi G, Polak J M, Turk J L
Department of Pathology, Royal College of Surgeons of England, London.
Neuropathol Appl Neurobiol. 1994 Jun;20(3):261-71. doi: 10.1111/j.1365-2990.1994.tb00968.x.
Nerve damage, resembling that caused by Mycobacterium leprae in man, was created by the injection of cobalt-irradiated M. leprae organisms into the tibial nerve of guinea-pigs. Assessment of nerve damage was made by clinical, electrophysiological and morphometric means at intervals up to 13 weeks after injection. Quantitative immunohistochemical analysis of neuropeptide-containing fibres in the skin of the foot was also carried out. Significant nerve damage occurred 3 weeks after injection of M. leprae organisms. Motor and sensory functional loss peaked at 5 weeks after injection, and there was a significant decrease of peptide-immunoreactive nerves in all skin compartments. The nerve damage was self-limiting and functional recovery had occurred by 13 weeks. The model shows many of the features found in the nerve damage of treated leprosy patients.
通过将经钴辐射的麻风分枝杆菌注入豚鼠的胫神经，造成了类似于人类麻风分枝杆菌所引起的神经损伤。在注射后长达13周的时间内，定期通过临床、电生理和形态测量方法对神经损伤进行评估。还对足部皮肤中含神经肽纤维进行了定量免疫组织化学分析。注射麻风分枝杆菌后3周出现了明显的神经损伤。运动和感觉功能丧失在注射后5周达到峰值，并且所有皮肤层中肽免疫反应性神经均显著减少。神经损伤是自限性的，到13周时功能已恢复。该模型显示出许多在接受治疗的麻风病人神经损伤中发现的特征。
