Silverman S E, Tran D B, Zimmerman K M, Feldon S E
Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.
Neurology. 1994 Oct;44(10):1814-8. doi: 10.1212/wnl.44.10.1814.
To better understand the damage to the motion pathway that occurs in senile dementia of the Alzheimer type (SDAT), we developed a system to assess separately the conscious perception and unconscious detection of motion in patients with SDAT. Motion perception thresholds were significantly elevated in SDAT (n = 9) compared with controls (n = 12), but motion detection thresholds were normal. This dissociation between the perception and detection of motion in early SDAT parallels histologic evidence of a disconnection between primary and association visual cortices. This disconnection may underlie the severe visual perception deficits seen in SDAT.
为了更好地理解阿尔茨海默型老年痴呆症（SDAT）中发生的运动通路损伤，我们开发了一种系统，用于分别评估SDAT患者对运动的有意识感知和无意识检测。与对照组（n = 12）相比，SDAT组（n = 9）的运动感知阈值显著升高，但运动检测阈值正常。早期SDAT中运动感知与检测之间的这种分离与初级视觉皮层和联合视觉皮层之间断开连接的组织学证据相似。这种断开连接可能是SDAT中严重视觉感知缺陷的基础。
