Dept. of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Accid Anal Prev. 2010 May;42(3):852-8. doi: 10.1016/j.aap.2009.07.009.
The aim of this study was to assess whether patients with neurodegenerative disease, namely Alzheimer's disease (AD) and Parkinson's disease (PD), differed from age-matched, neurologically normal comparison participants in their ability to detect impending collisions. Six AD patients and 8 PD patients, together comprising the neurodegenerative disease group, and 18 comparison participants completed a collision detection simulation task where they must judge whether approaching objects would collide with them or pass by them. The neurodegenerative disease group was less sensitive in detecting collisions than the comparison group, and sensitivity worsened with increasing number of objects in the display and increasing time to contact of those objects. Poor performance on tests of cognition and visual attention were associated with poor collision detection sensitivity. The results of this study indicate that neurodegenerative disease impairs the ability to accurately detect impending collisions and that these decrements are likely the combined result of visual and cognitive disturbances related to disease status.
本研究旨在评估神经退行性疾病患者（即阿尔茨海默病（AD）和帕金森病（PD））与年龄匹配的神经正常对照参与者在检测即将发生的碰撞方面是否存在差异。6 名 AD 患者和 8 名 PD 患者，共计 14 名神经退行性疾病患者，以及 18 名对照参与者完成了碰撞检测模拟任务，他们必须判断接近的物体是否会与他们发生碰撞或从他们身边经过。神经退行性疾病组检测碰撞的敏感性低于对照组，并且随着显示中的物体数量增加和物体接触时间增加，敏感性会恶化。认知和视觉注意力测试表现不佳与碰撞检测敏感性差有关。这项研究的结果表明，神经退行性疾病会损害准确检测即将发生的碰撞的能力，这些缺陷很可能是与疾病状态相关的视觉和认知障碍的综合结果。
