载脂蛋白Eε4等位基因在路易体变异型阿尔茨海默病患者中过度表达。
The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease.
作者信息
Galasko D, Saitoh T, Xia Y, Thal L J, Katzman R, Hill L R, Hansen L
机构信息
Veterans Affairs Medical Center, San Diego, CA 92161.
出版信息
Neurology. 1994 Oct;44(10):1950-1. doi: 10.1212/wnl.44.10.1950.
We determined apolipoprotein E (ApoE) genotypes in 122 autopsied demented patients. The frequency of the ApoE epsilon 4 allele was 39.6% in Alzheimer's disease (AD), 29.0% in the Lewy body variant of AD (LBV), and 6.25% in diffuse Lewy body disease. For AD and LBV patients, the epsilon 4 frequency was significantly higher than that reported in nondemented controls (10 to 15%). Therefore, LBV and AD share ApoE epsilon 4 as a genetic risk factor, providing further evidence that these conditions overlap.
我们对122例经尸检的痴呆患者进行了载脂蛋白E（ApoE）基因型测定。在阿尔茨海默病（AD）中，ApoE ε4等位基因的频率为39.6%，在AD路易体变异型（LBV）中为29.0%，在弥漫性路易体病中为6.25%。对于AD和LBV患者，ε4频率显著高于非痴呆对照者报告的频率（10%至15%）。因此，LBV和AD共有ApoE ε4作为遗传风险因素，这为这些病症存在重叠提供了进一步证据。
Zotero 插件