Bernardi P, Pace V
Istituto di Fisiologia Generale, Università degli Studi La Sapienza, Roma.
Minerva Ginecol. 1994 May;46(5):249-55.
The study aimed to verify the probable correlation between the incidence of cervical cancer and the presence of human papilloma virus (HPV) in relation to a state of folic acid hypovitaminosis. In this context, however, it is important not to overlook the important protective role played by vitamins A and C in cancer prevention, as mentioned in the paper. Numerous authors agree that this is a real finding in cervical pathology, as shown in our research, even if folic acid therapy does not alter the course and prognosis of disease. On the contrary, low blood levels of folic acid appear to increase the risk of contracting the disease. Extensive and radical surgery therefore appears to be even more justified in order to increase the probability of recovery on the operating table in view of the irrational and inexorable progress of this pathology, especially if metastases are already present.
该研究旨在验证宫颈癌发病率与人类乳头瘤病毒（HPV）的存在之间可能存在的关联，以及与叶酸维生素缺乏状态的关系。然而，在这种情况下，正如论文中所提到的，重要的是不要忽视维生素A和C在癌症预防中所起的重要保护作用。许多作者一致认为，正如我们的研究所表明的，这在宫颈病理学中是一个真实的发现，即使叶酸治疗不会改变疾病的进程和预后。相反，血液中叶酸水平低似乎会增加患该病的风险。因此，鉴于这种病理学不合理且不可阻挡的进展，特别是如果已经出现转移，进行广泛而彻底的手术似乎更有必要，以便提高手术台上康复的可能性。
