Baudet-Pommel M, Albuisson E, Kemeny J L, Falvard F, Ristori J M, Fraysse M P, Sauvezie B
Hôpital Gabriel-Montpied, Clermont-Ferrand.
Oral Surg Oral Med Oral Pathol. 1994 Aug;78(2):181-6. doi: 10.1016/0030-4220(94)90143-0.
Early dental loss is a well-known complication of Sjögren's syndrome. Forty percent (n = 16) of 39 consecutive patients with the syndrome had early dental loss. Dental loss correlated positively with histologic grading at lip biopsy. There was no significant correlation with any other feature of Sjögren's syndrome, including saliva flow. In 11 partially edentulous or completely edentulous patients, dental loss occurred 9 years on average before the first symptom of xerostomia. Early dental loss may reflect a silent involvement of the salivary glands and suggests that changes in saliva biochemistry occur long before xerostomia.
早期牙齿缺失是干燥综合征一种众所周知的并发症。在39例连续的该综合征患者中，40%（n = 16）有早期牙齿缺失。牙齿缺失与唇部活检的组织学分级呈正相关。与干燥综合征的任何其他特征（包括唾液流量）均无显著相关性。在11例部分缺牙或全口无牙的患者中，牙齿缺失平均发生在口干症首发症状出现前9年。早期牙齿缺失可能反映了唾液腺的隐匿性受累，并提示唾液生化改变早在口干症出现之前就已发生。
