Magro G, Lanzafame S, Colombatti A
Istituto di Anatomia ed Istologia Patologica, Università di Catania.
Pathologica. 1994 Apr;86(2):142-5.
Ten cases of primary invasive male breast ductal carcinomas (N.O.S.), one case of male breast fibroadenoma, seven cases of pure florid gynecomastia and four cases of normal mammary glands were examined immunohistochemically for type VI collagen expression and distribution. In normal male breast type VI collagen was absent in the whole fibrous stroma. On the contrary this collagen was markedly expressed in the stroma of invasive carcinoma as well as fibroadenoma and gynecomastia. In all these proliferative diseases, type VI collagen gave a distinct basement membrane-like deposition at the epithelial-stromal junctions while organized a fibrillar network in the interstitium. Our immunohistochemical findings showed that type VI collagens is involved in the stromal response of benign and malignant male breast proliferative diseases.
对10例原发性浸润性男性乳腺导管癌（未另行分类）、1例男性乳腺纤维腺瘤、7例单纯性增生性男性乳房肥大症以及4例正常乳腺进行了免疫组织化学检查，以检测VI型胶原的表达和分布情况。在正常男性乳腺中，整个纤维间质均未检测到VI型胶原。相反，在浸润性癌、纤维腺瘤和男性乳房肥大症的间质中，该胶原均有明显表达。在所有这些增生性疾病中，VI型胶原在上皮-间质交界处形成明显的基底膜样沉积，同时在间质中构成纤维网络。我们的免疫组织化学研究结果表明，VI型胶原参与了男性乳腺良恶性增生性疾病的间质反应。
