Kashyap S, Schulze K F, Ramakrishnan R, Dell R B, Heird W C
Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, New York 10032.
Pediatr Res. 1994 Jun;35(6):704-12. doi: 10.1203/00006450-199406000-00017.
A model for predicting the relationship between protein and energy intakes of low-birth-weight (LBW) infants and the rate and composition of weight gain is described. It is based on linear multiple regression equations summarizing the rates of weight gain, nitrogen retention, and energy retention of 101 previously studied LBW infants fed protein intakes ranging from 2.25 to 3.9 g.kg-1.d-1 and concomitant energy intakes ranging from 115 to 147 kcal.kg-1.d-1 plus current theory concerning nutrient retention and body composition. To test the validity of the model, three combinations of protein and energy intake predicted by the model to result in specific rates and compositions of weight gain were fed to 44 LBW infants, and the observed rates of weight gain, protein accretion, and fat accretion were compared with the rates predicted by the model. Differences in these and other outcome variables between two of the groups, the intakes of which differed only in energy, also were compared to provide additional insight into the effect of concomitant energy intake on protein utilization. Across groups, actual outcomes correlated closely with predicted outcomes, supporting the validity of the model for the total population. However, outcomes of individual infants deviated as much as 30% from predicted outcomes; the magnitude of the deviation was independent of birth weight, gestational age, or size for gestational age.(ABSTRACT TRUNCATED AT 250 WORDS)
本文描述了一个预测低体重（LBW）婴儿蛋白质和能量摄入量与体重增加速率及组成之间关系的模型。该模型基于线性多元回归方程，这些方程总结了101名先前研究的低体重婴儿的体重增加速率、氮保留率和能量保留率，这些婴儿摄入的蛋白质摄入量范围为2.25至3.9 g·kg⁻¹·d⁻¹，同时能量摄入量范围为115至147 kcal·kg⁻¹·d⁻¹，再加上有关营养保留和身体组成的当前理论。为了检验该模型的有效性，将模型预测的三种蛋白质和能量摄入组合（预计会导致特定的体重增加速率和组成）喂给44名低体重婴儿，并将观察到的体重增加速率、蛋白质积累和脂肪积累速率与模型预测的速率进行比较。还比较了两组（其摄入量仅在能量方面有所不同）之间这些及其他结果变量的差异，以进一步了解同时摄入能量对蛋白质利用的影响。在所有组中，实际结果与预测结果密切相关，支持了该模型对总体人群的有效性。然而，个别婴儿的结果与预测结果的偏差高达30%；偏差的大小与出生体重、胎龄或胎龄大小无关。（摘要截短于250字）
