Fasman K H, Cuticchia A J, Kingsbury D T
Johns Hopkins University School of Medicine, Baltimore, MD 21205-2100.
Nucleic Acids Res. 1994 Sep;22(17):3462-9. doi: 10.1093/nar/22.17.3462.
In 1991 the Genome Data Base at Johns Hopkins University School of Medicine was selected as the central repository for mapping data from the Human Genome Project, and was funded by NIH and DOE under a three year award. GDB has now finished 28 months of Federally funded operation. During this period a great deal of progress and many internal changes have taken place. In addition, many changes have also occurred in the external environment, and GDB has adapted its strategies to play an appropriate role in those changes as well. Recognizing the central role of mapping information in the genome project, it is important that GDB respond aggressively to the increasing demands of genomic researchers, as well as formulate a program of response to a number of long standing, but still unmet, needs of that community. It is even more important that GDB provide leadership in the genome informatics enterprise. Three themes described here are dominant in our future plans and represent the essence of the major changes made in the past year. They include: enhanced data acquisition, better map representation, and full integration into the collection of genomic databases.
1991年,约翰·霍普金斯大学医学院的基因组数据库被选为人类基因组计划图谱数据的中央储存库,并由美国国立卫生研究院(NIH)和美国能源部(DOE)提供为期三年的资助。GDB现已完成了28个月由联邦政府资助的运作。在此期间,取得了很大进展,内部也发生了许多变化。此外,外部环境也发生了许多变化,GDB也调整了其策略,以便在这些变化中发挥适当作用。认识到图谱信息在基因组计划中的核心作用,GDB积极响应基因组研究人员日益增长的需求,并制定应对该领域一些长期存在但仍未得到满足的需求的计划,这一点很重要。更重要的是,GDB要在基因组信息学事业中发挥领导作用。这里描述的三个主题在我们未来的计划中占主导地位,代表了过去一年所做主要变化的实质。它们包括:加强数据采集、更好地呈现图谱以及全面融入基因组数据库集合。