硫唑嘌呤治疗特发性膜性肾小球肾炎继发肾病综合征的对照试验
Controlled trial of azathioprine in the nephrotic syndrome secondary to idiopathic membranous glomerulonephritis.
出版信息
Can Med Assoc J. 1976 Dec 18;115(12):1209-10.
Abstract
In a controlled double-blind trial five patients with the nephrotic syndrome due to idiopathic membranous glomerulonephritis received azathioprine, 2.5 mg/kg-d, while four others received placebo. After 1 year of treatment there was no significant difference between the two groups with regard to the changes in leukocyte count, values for hemoglobin, serum creatinine, blood urea nitrogen or serum albumin, 24-hour excretion of protein in the urine, or creatinine clearance. In this study azathiprine appeared not to be useful in the treatment of idiopathic membranous glomerulonephritis.
摘要
在一项对照双盲试验中，5例因特发性膜性肾小球肾炎导致肾病综合征的患者接受硫唑嘌呤治疗，剂量为2.5毫克/千克/天，另外4例患者接受安慰剂治疗。治疗1年后，两组在白细胞计数变化、血红蛋白值、血清肌酐、血尿素氮或血清白蛋白、24小时尿蛋白排泄量或肌酐清除率方面均无显著差异。在这项研究中，硫唑嘌呤似乎对特发性膜性肾小球肾炎的治疗无效。
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