[去酪氨酸-D-苯丙氨酸3]β-酪蛋白吗啡（2-5）对大鼠皮层脑电图功率谱的影响。

Effects of [des-Tyr-D-Phe3]beta-casomorphin (2-5) on cortical EEG power spectra in rats.

作者信息

Diedrich M, Schulz S, Wetzel W

机构信息

Institute of Neurobiology, Magdeburg, Germany.

出版信息

Peptides. 1994;15(4):667-70. doi: 10.1016/0196-9781(94)90093-0.

DOI:10.1016/0196-9781(94)90093-0

PMID:7937343

Abstract

The effects of the peptide [des-Tyr-D-Phe3]beta-casomorphin(2-5) (BCH-325; Pro-D-Phe-Pro-Gly; 2.27, 22.7, and 227 micrograms/kg) on cortical EEG power spectra in rats were studied compared to those of other psychotropic drugs, including diazepam, amitriptyline, haloperidol, and amphetamine. All drugs were injected IP, and cortical EEG power spectra were recorded from freely moving rats for 2 h postinjection. Administration of 22.7 and 227 micrograms/kg BCH-325 resulted in an increase in alpha-2 and beta-1 frequency bands and a decrease in slower frequencies (delta, theta). Our findings show that the effects of BCH-325 on cortical EEG power spectra differ from those of other psychotropic drugs.

摘要

将肽[去酪氨酸-D-苯丙氨酸3]β-酪蛋白吗啡(2-5)(BCH-325；脯氨酸-D-苯丙氨酸-脯氨酸-甘氨酸；2.27、22.7和227微克/千克)对大鼠皮层脑电图功率谱的影响与其他精神药物，包括地西泮、阿米替林、氟哌啶醇和苯丙胺进行了比较研究。所有药物均腹腔注射，在注射后2小时对自由活动的大鼠记录皮层脑电图功率谱。给予22.7和227微克/千克的BCH-325导致α-2和β-1频段增加，较慢频率(δ、θ)降低。我们的研究结果表明，BCH-325对皮层脑电图功率谱的影响与其他精神药物不同。