脑二烯：一种从睡眠剥夺的猫脑中分离出的脑脂质。
Cerebrodiene: a brain lipid isolated from sleep-deprived cats.
作者信息
Lerner R A, Siuzdak G, Prospero-Garcia O, Henriksen S J, Boger D L, Cravatt B F
机构信息
Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037.
出版信息
Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9505-8. doi: 10.1073/pnas.91.20.9505.
Abstract
We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.
摘要
我们报告了一种迄今未被识别的脑脂质的分离情况，该脂质存在于睡眠剥夺猫的脑脊液中。该分子似乎是一种与鞘氨醇和二氢鞘氨醇结构相关的长链碱，其中引入了第二个不饱和键。关键膜成分不饱和度的增加预计会产生重要的生理后果。
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