De S, Ravishankar B, Bhavsar G C
Institute of Post-Graduate Teaching and Research, Gujarat Ayurved University, Dhanvantari Mandir, Jamnagar, India.
Planta Med. 1994 Aug;60(4):301-4. doi: 10.1055/s-2006-959488.
The methanol extract of the defatted leaves of Gymnosporia montana was evaluated for hepatoprotective activity by noting its effect on carbon tetrachloride (CCl4)-induced changes in liver cytoarchitecture and alterations in certain biochemical parameters. The main parameters studied were transaminase activity, lipid constituents of serum and liver, orosomucoid level in serum, and liver glycogen and phospholipid contents. The extract administration led to a significant reversal of the majority of the altered biochemical parameters. Besides, a significant antagonism of the CCl4-induced changes in the liver cytoarchitecture was also observed. The results confirm the presence of hepatoprotective activity in the plant material.
通过观察其对四氯化碳（CCl₄）诱导的肝脏细胞结构变化和某些生化参数改变的影响，对山地裸实脱脂叶的甲醇提取物进行了保肝活性评估。研究的主要参数包括转氨酶活性、血清和肝脏的脂质成分、血清中类粘蛋白水平以及肝脏糖原和磷脂含量。提取物给药导致大多数改变的生化参数显著逆转。此外，还观察到对CCl₄诱导的肝脏细胞结构变化有显著拮抗作用。结果证实了该植物材料中存在保肝活性。
