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[甲癣的致病因子]

[Causal agents of onychomycosis].

作者信息

Canteros G E, Davel G O, Vivot W

机构信息

Instituto Nacional de Microbiología Dr. Carlos G. Malbrán, Buenos Aires, Argentina.

出版信息

Rev Argent Microbiol. 1994 Apr-Jun;26(2):65-71.

PMID:7938504
Abstract

The results obtained with 307 specimens from putatively immunocompetent patients between May 1991 and May 1992 were reviewed, to determine the frequency of isolation of fungal species causing onychomycoses. Sixty eight percent of the specimen were positive for microscopic examination and/or cultures. Onychomycoses occurred with double frequency in women than in men (Table 1), and 77% of cases were diagnosed in patients aged between 30 and 70 years (Figure 1). Out of 182 patients with positive cultures, 60% were affected by dermatophytes and 39% by yeasts; molds (Aspergillus spp.) were isolated in only two cases (Table 3). Neither Corynebacterium spp., nor Malasezzia furfur were detected. In toe nails Trichophyton rubrum predominated over yeasts being isolated in 72.9% of the cases; yeasts other than Candida albicans were isolated in 12.3%, Trichophyton mentagrophytes in 10%, while Aspergillus spp., C. albicans and Epidermophyton floccosum in only 1.6%. On the other hand, in finger nails yeasts predominated: C. albicans was isolated in 46.7% of cases, other yeasts in 43.3%; and T. rubrum in the remaining 10%. Out of 41 isolations of yeasts other than C. albicans, 42% were C. parapsilosis, 16% Debaryomyces hansenii, 6% C. pulcherrima, 6% Trichosporum cutaneum and 6% C. famata (Figure 2).

摘要

回顾了1991年5月至1992年5月间从假定免疫功能正常的患者身上获取的307份标本的检测结果,以确定引起甲癣的真菌种类的分离频率。68%的标本显微镜检查和/或培养呈阳性。甲癣在女性中的发生率是男性的两倍(表1),77%的病例诊断于30至70岁的患者(图1)。在182例培养阳性的患者中,60%感染皮肤癣菌,39%感染酵母菌;仅在两例中分离出霉菌(曲霉菌属)(表3)。未检测到棒状杆菌属和糠秕马拉色菌。在趾甲中,红色毛癣菌占主导,72.9%的病例分离出该菌;白色念珠菌以外的酵母菌分离率为12.3%,须癣毛癣菌为10%,而曲霉菌属、白色念珠菌和絮状表皮癣菌仅为1.6%。另一方面,在指甲中酵母菌占主导:白色念珠菌分离率为46.7%,其他酵母菌为43.3%;其余10%为红色毛癣菌。在41例白色念珠菌以外的酵母菌分离病例中,42%为近平滑念珠菌,16%为汉逊德巴利酵母,6%为季也蒙念珠菌,6%为皮肤毛孢子菌,6%为法塔念珠菌(图2)。

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