Jack C I, Walshaw M J, Tran J, Hind C R, Evans C C
Cardiothoracic Centre, Liverpool, U.K.
Respir Med. 1994 Jul;88(6):441-4. doi: 10.1016/s0954-6111(05)80047-2.
Prolonged oesophageal pH monitoring is commonly used in the investigation of gastro-oesophageal reflux. In contrast, tracheal pH monitoring is virtually unknown. We report a simple technique of measuring tracheal pH where the pH probe is inserted under local anaesthetic and can be left in position for 24 h to allow prolonged monitoring. Ten control individuals were studied. All completed the study without complication. One patient with mixed connective tissue disease, failed hiatal hernia repair and subsequent recurrent aspiration pneumonia was studied, on and off ranitidine, using simultaneous tracheal and oesophageal pH monitoring. This method showed evidence of gastro-oesophageal reflux and tracheal aspiration off treatment. When repeated with the patient taking ranitidine, the frequency of significant gastro-oesophageal reflux was reduced and no episodes of tracheal acid aspiration were recorded. Prolonged tracheal pH monitoring is a simple and non-hazardous technique. It is sensitive in detecting tracheal aspiration and may be more sensitive than pre-existing radiolabelled isotope techniques.
长时间食管pH监测常用于胃食管反流的研究。相比之下,气管pH监测实际上并不为人所知。我们报告一种测量气管pH的简单技术,即pH探头在局部麻醉下插入,可留置24小时以进行长时间监测。对10名对照个体进行了研究。所有人均顺利完成研究,无并发症发生。对一名患有混合性结缔组织病、食管裂孔疝修补失败且随后反复发生吸入性肺炎的患者,在服用雷尼替丁前后,同时进行气管和食管pH监测。该方法显示出在未治疗时存在胃食管反流和气管误吸的证据。当患者服用雷尼替丁后重复监测时,显著胃食管反流的频率降低,且未记录到气管酸误吸事件。长时间气管pH监测是一种简单且无风险的技术。它在检测气管误吸方面很敏感,可能比现有的放射性同位素技术更敏感。