Prada Pardal J L, Villanueva Marcos J L, Kindelán Jaquotot J M, Jurado Jiménez R, Escribano Fernández J, Sánchez Guijo P, Torre-Cisneros J
Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sofía, Córdoba.
Rev Clin Esp. 1994 Jul;194(7):547-50.
Cavitary lung lesions are common in intravenous drug-addicts (IVDA) and in AIDS patients. Four cases are reported of IVDA patients with HIV positive serology who developed an initially thick-walled lesion, which grew rapidly and evolved into bullous lesions. The negative results in microbiological investigations for Pneumocystis carinii, Nocardia spp., staphylococci; the topographic superposition on a previous tuberculous lesion; a prolonged asymptomatic period; and a particularly rapid evolution in all cases led us to consider the rapidly evolving bullous degeneration to be more than a casual finding. Previous infection with M. tuberculosis in AIDS patients might somehow influence on the later development of a rapidly growing, fatal, bullous degenerative lesion. The elucidation of the pathogenic mechanisms of these lesions was hampered by the lack of pathological studies.
空洞性肺部病变在静脉注射吸毒者（IVDA）和艾滋病患者中很常见。本文报告了4例血清学HIV阳性的IVDA患者，他们最初出现厚壁病变，病变迅速增大并演变成大疱性病变。卡氏肺孢子虫、诺卡菌属、葡萄球菌的微生物学检查结果均为阴性；病变在先前结核病灶的部位重叠；无症状期延长；以及所有病例中病变演变特别迅速，这些因素使我们认为迅速演变的大疱性退变不仅仅是一个偶然发现。艾滋病患者先前感染结核分枝杆菌可能会以某种方式影响快速生长、致命的大疱性退变病变的后期发展。由于缺乏病理研究，这些病变的致病机制难以阐明。
