Mignon M, Lamorthe B, Cadiot G
Service d'hépato-gastro-entérologie et GRESZE, CHU Bichat-Claude-Bernard, Paris.
Rev Prat. 1994 Jun 15;44(12):1620-8.
Medical management of patients with Zollinger-Ellison syndrome has considerably evolved since initial reports in 1955 and especially over the last decade. Control of gastric hypersecretion by effective antisecretory drugs, accurate localization and staging of the tumoral process by modern medical imaging techniques as well as progress in surgical skill undoubtedly account for higher rates of gastrinoma definitive or long-lasting cure. Elective surgery for gastrinoma removal may indeed be safely undertaken in selected patients. Current diagnostic and treatment strategies have been discussed here, by reference to the literature and a large personal series of patients followed at Bichat-Claude-Bernard Hospital for 30 years. The specific case of gastrinoma associated with multiple endocrine neoplasia type I is also discussed.
自1955年首次报道以来，尤其是在过去十年中，卓-艾综合征患者的医学管理有了很大进展。有效的抗分泌药物对胃酸分泌过多的控制、现代医学成像技术对肿瘤进程的准确定位和分期以及手术技术的进步，无疑是胃泌素瘤得到明确或持久治愈的比例更高的原因。对于选定的患者，确实可以安全地进行择期手术切除胃泌素瘤。本文通过参考文献以及在比夏-克劳德-贝尔纳医院随访30年的大量个人病例系列，讨论了当前的诊断和治疗策略。还讨论了与I型多发性内分泌肿瘤相关的胃泌素瘤的特殊情况。
