Altura B T, Altura B M
Department of Physiology, State University of New York, Health Science Center at Brooklyn 11203.
Scand J Clin Lab Invest Suppl. 1994;217:83-7. doi: 10.3109/00365519409095214.
Since 1932, it has been known that Mg exists in blood in several forms: protein-bound, complexed to certain anions, and ionized. However, there is discrepancy and debate on what these fractions are, how to accurately assess them, and whether they are important in diagnosis and prognosis of disease syndromes. Using the NOVA ISE for IMg2+, a controlled method for ultrafiltration of Mg and atomic absorption spectrophotometry, we have found four distinct fractions of Mg in healthy normal plasma and serum: 1. ultrafilterable Mg (81%) (made up of ionized and complexed); 2. ionized Mg (67%); 3. protein-bound Mg (19%); and 4. complexed Mg (14%). The amount of each fraction appears to depend upon the pathophysiologic state of the patients. Previous observations on the amount of complexed and ionized Mg are at best, only approximations, due to the absence of a device (i.e., ISE) to measure accurately IMg2+.
自1932年以来，人们就知道镁在血液中以多种形式存在：与蛋白质结合、与某些阴离子络合以及离子化形式。然而，关于这些组分是什么、如何准确评估它们以及它们在疾病综合征的诊断和预后中是否重要，存在分歧和争议。使用用于测定离子化镁（IMg2+）的NOVA离子选择性电极、一种用于镁超滤的可控方法以及原子吸收分光光度法，我们在健康正常血浆和血清中发现了四种不同的镁组分：1. 可超滤镁（81%）（由离子化和络合形式组成）；2. 离子化镁（67%）；3. 蛋白质结合镁（19%）；4. 络合镁（14%）。每种组分的量似乎取决于患者的病理生理状态。由于缺乏准确测量IMg2+的设备（即离子选择性电极），之前关于络合镁和离子化镁含量的观察充其量只是近似值。
