Larsson P, Roos G, Stenling R, Ljungberg B
Department of Urology & Andrology, University of Umeå, Sweden.
Scand J Urol Nephrol. 1994 Jun;28(2):135-40. doi: 10.3109/00365599409180489.
Tumor cell proliferation is one interesting cell biological parameter of possible predictive value for prognosis. In the present study 176 tumor and 33 kidney cortex samples from 33 patients with renal cell carcinoma were studied after immunohistochemical detection of in vivo labelled iododeoxyuridine. The tumors had a mean labelling index (LI) of 1.06 +/- 0.59%, significantly different from LI of kidney cortex tissue 0.08 +/- 0.09% (p < 0.001). There was a tendency towards increasing LIs at higher clinical stages. No correlation was found between LI and tumor size. A significant difference existed for LIs between diploid and aneuploid tumors (p = 0.037). Within the limited number of patients with a relatively short follow-up, Kaplan-Meier curves indicated that LI might provide prognostic information.
肿瘤细胞增殖是一个对预后可能具有预测价值的有趣细胞生物学参数。在本研究中，对33例肾细胞癌患者的176个肿瘤样本和33个肾皮质样本进行了体内标记碘脱氧尿苷的免疫组化检测。肿瘤的平均标记指数（LI）为1.06±0.59%，与肾皮质组织的LI 0.08±0.09%有显著差异（p<0.001）。在较高临床分期时，LI有增加的趋势。未发现LI与肿瘤大小之间存在相关性。二倍体和非整倍体肿瘤的LI存在显著差异（p = 0.037）。在随访时间相对较短的有限患者数量中，Kaplan-Meier曲线表明LI可能提供预后信息。
