Abe A, Urano K
Kanagawa Environmental Research Center, Hiratsuka, Japan.
Sci Total Environ. 1994 Aug 15;153(1-2):169-75. doi: 10.1016/0048-9697(94)90113-9.
The influence of 16 organic chemicals commonly found in a water environment--such as phenols, phthalic esters and phosphoric esters--on the Salmonella mutagenicity test was investigated. The test chemicals were subjected to the mutagenicity test using a fixed dose of various positive standard mutagens such as 2-nitrofluorene, Trp-P-1, Trp-P-2, 2-aminofluorene and benzo[a]pyrene, thus testing them for their influence on the mutagenic activities. The influence of each chemical was classified into one of five groups as follows: (1) toxic and inhibitory to mutagenicity; (2) toxic and promotive to mutagenicity; (3) non-toxic and inhibitory to mutagenicity; (4) non-toxic and promotive to mutagenicity; and (5) non-toxic and having no effect on mutagenicity. It is concluded that chemicals in the water environment may influence the results of a mutagenicity test on environmental samples. In particular, an effect may be noted with regard to wastewater and sediments which contain these chemicals in higher concentrations eventhough they themselves are not mutagenic.
研究了水环境中常见的16种有机化学物质（如酚类、邻苯二甲酸酯和磷酸酯）对沙门氏菌致突变性试验的影响。使用固定剂量的各种阳性标准诱变剂（如2-硝基芴、Trp-P-1、Trp-P-2、2-氨基芴和苯并[a]芘）对受试化学物质进行致突变性试验，从而测试它们对诱变活性的影响。每种化学物质的影响分为以下五组之一：（1）有毒且抑制致突变性；（2）有毒且促进致突变性；（3）无毒且抑制致突变性；（4）无毒且促进致突变性；（5）无毒且对致突变性无影响。得出的结论是，水环境中的化学物质可能会影响环境样品致突变性试验的结果。特别是，对于含有较高浓度这些化学物质的废水和沉积物，即使它们本身没有致突变性，也可能会观察到影响。
