蛋白激酶Raf-1与14-3-3蛋白的相互作用。
Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
作者信息
Fu H, Xia K, Pallas D C, Cui C, Conroy K, Narsimhan R P, Mamon H, Collier R J, Roberts T M
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.
出版信息
Science. 1994 Oct 7;266(5182):126-9. doi: 10.1126/science.7939632.
Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to associate with Raf-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Raf-1. The association of 14-3-3 proteins and Raf-1 was not substantially affected by the activation state of Raf.
通过多种实验方法发现，一类高度保守的蛋白质家族成员，即14-3-3蛋白，与Raf-1相关联，Raf-1是关键信号转导途径的核心成分。最佳复合物形成需要Raf-1的氨基末端调节结构域。14-3-3蛋白与Raf-1的关联基本上不受Raf激活状态的影响。
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