Chiew Y F
Department of Laboratory Medicine, National University Hospital, Singapore.
Singapore Med J. 1994 Apr;35(2):177-9.
Five clinical cases of enterococcal septicaemia were studied retrospectively including determination of high-level aminoglycoside resistance (HLAR) to gentamicin, streptomycin and kanamycin. This is the first study of its kind in Singapore. The clinical features and risk factors for this illness were analysed and found to be very similar to enterococcal bacteremia in general. It is important to carry out tests to detect HLAR so that unnecessary aminoglycoside toxicity can be prevented or to decide on the appropriate aminoglycoside to combine with a cell wall-active agent in severe enterococcal sepsis.
我们对5例肠球菌败血症临床病例进行了回顾性研究，包括测定对庆大霉素、链霉素和卡那霉素的高水平氨基糖苷类耐药性（HLAR）。这是新加坡首例此类研究。我们分析了这种疾病的临床特征和危险因素，发现总体上与肠球菌菌血症非常相似。进行检测以发现HLAR很重要，这样可以预防不必要的氨基糖苷类毒性，或者在严重肠球菌败血症中决定与细胞壁活性剂联合使用的合适氨基糖苷类药物。
