噬菌体依赖型福氏志贺氏菌抗原合成的变化
Phage-dependent changes in Shigella flexneri type antigen synthesis.
作者信息
Financsek I, Ketyi I, Sasak W, Jankowski W, Janczura E, Chojnacki T
出版信息
Infect Immun. 1976 Dec;14(6):1290-2. doi: 10.1128/iai.14.6.1290-1292.1976.
Abstract
Lysogenic conversion of Shigella flexneri type antigens was studied with the aid of wild-type and thermosensitive mutant phages. With all wild-type phages, the appearance of glycosylated antigen was accompanied by the appearance of polyprenyl phosphate glucose synthetase activity. With some of the mutant phages, the appearance of glycosylated antigen was not followed by the formation of lipid-linked glucose in the enzyme assay. The reverse has also been observed, i.e., the high rate of formation of lipid-linked glucose and the lack of V-type antigen.
摘要
利用野生型和温度敏感型突变噬菌体研究了福氏志贺氏菌型抗原的溶原性转化。对于所有野生型噬菌体，糖基化抗原的出现伴随着聚异戊二烯磷酸葡萄糖合成酶活性的出现。对于一些突变噬菌体，在酶分析中，糖基化抗原出现后并未形成脂质连接的葡萄糖。也观察到了相反的情况，即脂质连接的葡萄糖形成率高且缺乏V型抗原。
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