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器官保存

Organ preservation.

作者信息

D'Alessandro A M, Southard J H, Love R B, Belzer F O

机构信息

Department of Surgery, University of Wisconsin Medical School, Madison.

出版信息

Surg Clin North Am. 1994 Oct;74(5):1083-95.

PMID:7940062
Abstract

Our clinical transplantation results have been very satisfying, with about 90% graft survival after 1 year. Currently, preservation of the liver, pancreas, and kidney, although not ideal, appears to meet all our clinical needs. Improvements in heart and lung preservation are needed and will result in increasing the number of cadaveric organs available for patients with end-stage intrathoracic organ diseases. In the future, machine perfusion may become the standard method for organ preservation for most organs because of the excellent preservation results and long-term preservation achieved.

摘要

我们的临床移植结果非常令人满意,1年后移植物存活率约为90%。目前,肝脏、胰腺和肾脏的保存虽然并不理想,但似乎能满足我们所有的临床需求。心脏和肺脏保存方面需要改进,这将增加可用于终末期胸内器官疾病患者的尸体器官数量。未来,由于机器灌注取得的出色保存效果和长期保存成果,它可能会成为大多数器官保存的标准方法。

相似文献

1
Organ preservation.器官保存
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2
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Calcium-supplemented University of Wisconsin solution in long-term myocardial preservation.补充钙的威斯康星大学溶液用于长期心肌保存。
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The effect of machine perfusion preservation versus cold storage on the function of kidneys from non-heart-beating donors.机器灌注保存与冷藏对非心脏跳动供体肾脏功能的影响。
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Experience with hystidine tryptophan ketoglutarate versus University Wisconsin preservation solutions in transplantation.组氨酸-色氨酸-酮戊二酸保存液与威斯康星大学保存液在移植中的应用经验比较
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Isochoric Supercooling Organ Preservation System.等容过冷器官保存系统
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Development and Characterization of a Nonelectronic Versatile Oxygenating Perfusion System for Tissue Preservation.开发和描述一种非电子多功能充氧灌注系统,用于组织保存。
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Adding the oxygen carrier M101 to a cold-storage solution could be an alternative to HOPE for liver graft preservation.
在冷藏溶液中添加氧载体M101可能是肝脏移植保存中替代HOPE的一种方法。
JHEP Rep. 2020 May 8;2(4):100119. doi: 10.1016/j.jhepr.2020.100119. eCollection 2020 Aug.
4
Survey of Apoptosis After Hypothermic Storage of a Pancreatic β-Cell Line.胰腺β细胞系低温保存后的凋亡研究
Biopreserv Biobank. 2016 Aug;14(4):271-8. doi: 10.1089/bio.2015.0060. Epub 2016 Mar 3.
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Cryopreservation of Endothelial Cells in Various Cryoprotective Agents and Media - Vitrification versus Slow Freezing Methods.不同冷冻保护剂和培养基中内皮细胞的冷冻保存——玻璃化冷冻与慢速冷冻方法
PLoS One. 2016 Feb 18;11(2):e0149660. doi: 10.1371/journal.pone.0149660. eCollection 2016.
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Development of pancreas storage solutions: Initial screening of cytoprotective supplements for β-cell survival and metabolic status after hypothermic storage.胰腺保存溶液的研发:低温保存后用于β细胞存活和代谢状态的细胞保护补充剂的初步筛选。
Biopreserv Biobank. 2013 Feb;11(1):12-8. doi: 10.1089/bio.2012.0023. Epub 2013 Feb 6.
7
Delayed graft function in the kidney transplant.移植肾延迟功能恢复。
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8
Flow distribution during infusion of UW and HTK solution in anaesthetised rats.UW 和 HTK 溶液输注期间麻醉大鼠的血流分布。
Langenbecks Arch Surg. 2011 Jun;396(5):677-83. doi: 10.1007/s00423-011-0747-1. Epub 2011 Feb 16.
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Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism.用26摄氏度空气饱和的利福溶液对豚鼠离体心脏进行低流量灌注20小时可维持其功能和代谢。
J Heart Lung Transplant. 2008 Sep;27(9):1008-15. doi: 10.1016/j.healun.2008.05.028. Epub 2008 Jul 26.
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Organ preservation solutions increase endothelial permeability and promote loss of junctional proteins.器官保存液会增加内皮细胞通透性并促进连接蛋白的丢失。
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