McGrail K M, Ojemann R G
Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C. 20007.
Surg Neurol. 1994 Jul;42(1):2-7. doi: 10.1016/0090-3019(94)90241-0.
Over a 22-year-period (1967-1989) 80 patients 70 years of age and older underwent surgery for resection of a benign intracranial tumor. This group included 56 meningiomas and 24 acoustic neuromas. Forty-five of the tumors were completely excised, whereas 35 were partially removed. Tumor regrowth was documented in seven patients during the follow-up period, five of whom underwent additional surgery for resection of recurrent tumor. Thirty-six (64.3%) of the patients with meningiomas had only a minimal or no preoperative neurologic deficit, whereas twenty (35.7%) had a major deficit. Fifty-three (94.6%) patients who underwent surgery for resection of their meningioma made a good recovery (48 were improved or unchanged and five had minimal nonincapacitating worsening), one (1.8%) was worse, and two (3.6%) died. Fourteen (58.3%) of the patients with acoustic neuromas had only a minimal or no preoperative neurologic deficit, whereas 10 (41.7%) had a major deficit. Twenty-two (91.7%) of the patients who underwent surgery for resection of their acoustic neuroma made a good recovery (18 were improved or unchanged and four had minimal nonincapacitating worsening), two (8.3%) were worse, and none died. We conclude that, when indicated, surgery for intracranial meningiomas and schwannomas can be offered to patients 70 years of age and older with acceptable morbidity and mortality.
在22年期间(1967 - 1989年),80名70岁及以上的患者接受了颅内良性肿瘤切除术。该组包括56例脑膜瘤和24例听神经瘤。45例肿瘤被完全切除,35例被部分切除。在随访期间,7例患者记录到肿瘤复发,其中5例接受了复发性肿瘤切除的额外手术。36例(64.3%)脑膜瘤患者术前仅有轻微或无神经功能缺损,而20例(35.7%)有严重缺损。53例(94.6%)接受脑膜瘤切除术的患者恢复良好(48例改善或无变化,5例有轻微无致残性恶化),1例(1.8%)情况恶化,2例(3.6%)死亡。14例(58.3%)听神经瘤患者术前仅有轻微或无神经功能缺损,而10例(41.7%)有严重缺损。22例(91.7%)接受听神经瘤切除术的患者恢复良好(18例改善或无变化,4例有轻微无致残性恶化),2例(8.3%)情况恶化,无死亡病例。我们得出结论,在有指征时,对于70岁及以上的患者,颅内脑膜瘤和神经鞘瘤手术的发病率和死亡率是可接受的。