Elves M W, Gray J C, Thorogood P V
J Anat. 1976 Nov;122(Pt 2):253-69.
The cell population within and around allografts of fresh, marrow-containing cortical bone has been studied. The grafts were implanted into intramuscular sites in rats and removed at intervals over a 4 week period for examination by light and electron microscopy to establish the sequence of changes at both the tissue and cellular levels. The tissue organization and the ultrastructural appearances of the cells found at different times after grafting are described; the possible relationships of the different cell types to each other and their likely roles in both the immunological and histogenic events are postulated and discussed. A comparison of the observations in the allograft and in the previously studied autograft suggests that the cells from the granulationtissue that become osteoblasts in the autograft differentiate into fibrocytes and giant cells in the allograft. Furthermore, the increased period of initial degeneration observed in the allograft (2 weeks) compared with the autograft (less than 1 week) may represent the destruction of early, graft-derived attempts at osteogenesis. This, together with the relative paucity of new bone in the allograft, suggests that some cells of graft origin may contribute to the early osteogenesis observed in the autograft.
对含有骨髓的新鲜皮质骨同种异体移植物内部及周围的细胞群体进行了研究。将移植物植入大鼠的肌肉部位，并在4周内每隔一段时间取出，通过光学显微镜和电子显微镜进行检查，以确定组织和细胞水平上的变化顺序。描述了移植后不同时间发现的组织结构和细胞的超微结构外观；推测并讨论了不同细胞类型之间可能的相互关系及其在免疫和组织发生事件中的可能作用。同种异体移植物和先前研究的自体移植物的观察结果比较表明，自体移植物中形成成骨细胞的肉芽组织细胞在同种异体移植物中分化为纤维细胞和巨细胞。此外，与自体移植物（少于1周）相比，同种异体移植物中观察到的初始退变期延长（2周）可能代表早期移植来源的成骨尝试遭到破坏。这一点，再加上同种异体移植物中新生骨相对较少，表明一些移植来源的细胞可能有助于自体移植物中观察到的早期成骨。
