Chiu I S, Chiang F T, How S W
Department of Surgery, National Taiwan University Hospital, Taipei.
Thorac Cardiovasc Surg. 1994 Jun;42(3):158-61. doi: 10.1055/s-2007-1016479.
To explain the lower atrial natriuretic peptide concentrations after total cavopulmonary connection than after the Fontan procedure, a prospective study was carried out in seven rats to count the specific granules of atrial natriuretic peptide by electronmicroscope. After fasting from water for 12 days, the quantity of specific granules in the right atrial appendage (pectinated part), intercaval sinus (smooth part), and superior vena cava were counted. The number of specific granules present in the pectinated part of right atrium was 97 +/- 19 in 20 cells, while in the intercaval sinus it was 23 +/- 19 (mean +/- SD). The difference was significant statistically (p < 0.0001). No granule was present in the superior vena cava. We conclude that the granularity of atrial natriuretic peptide is less in the intercaval sinus than the pectinated part of the right atrium.
为了解全腔静脉肺动脉连接术后心房利钠肽浓度低于Fontan手术后的原因，对7只大鼠进行了一项前瞻性研究，通过电子显微镜计数心房利钠肽的特异性颗粒。禁食水12天后，对右心耳（梳状部）、腔静脉间窦（光滑部）和上腔静脉中的特异性颗粒数量进行计数。右心房梳状部20个细胞中存在的特异性颗粒数量为97±19，而腔静脉间窦中为23±19（平均值±标准差）。差异具有统计学意义（p<0.0001）。上腔静脉中未发现颗粒。我们得出结论，腔静脉间窦中心房利钠肽的颗粒度低于右心房梳状部。
