Eukaryotic replication origins: control in space and time.

Replication origins facilitate the choreography of genome duplication by acting as targets for regulatory mechanisms. Eukaryotic cells control the efficiency and the time of origin activity. In addition, origins that have been replicated are prevented from doing so twice in the same cell cycle. In this review we will examine the mechanisms that may be used to control these processes, and discuss the role of replication in regulating transcription.