Allen T M
Department of Pharmacology, University of Alberta, Edmonton, Canada.
Trends Pharmacol Sci. 1994 Jul;15(7):215-20. doi: 10.1016/0165-6147(94)90314-x.
Anticancer chemotherapy is limited by adverse side-effects resulting from toxicities to normal tissues. Targeted delivery of drugs to diseased tissues in vivo would help to reduce these side-effects. Liposomes containing lipid derivatives of polyethylene glycol (sterically stabilized liposomes) have circulation times that are sufficiently long to allow for effective in vivo drug delivery, and are discussed in this review by Theresa Allen. Sterically stabilized liposomes, containing entrapped doxorubicin, targeted to squamous cell lung carcinoma by means of specific antibodies attached at the liposome surface are capable of reducing tumour burden to a significant extent and eradicating tumour in a significant percentage of mice.
抗癌化疗受到对正常组织产生毒性所导致的不良副作用的限制。将药物体内靶向递送至患病组织将有助于减少这些副作用。含有聚乙二醇脂质衍生物的脂质体（空间稳定脂质体）具有足够长的循环时间，以实现有效的体内药物递送，Theresa Allen在本综述中对此进行了讨论。通过附着在脂质体表面的特异性抗体靶向鳞状细胞肺癌的包封阿霉素的空间稳定脂质体能够在很大程度上减轻肿瘤负担，并在相当比例的小鼠中根除肿瘤。
