Larionova L V
Zh Mikrobiol Epidemiol Immunobiol. 1994 May-Jun(3):26-8.
In this study a search for F. tularensis antiphagocytic factor and an attempt for its isolation were made. For this purpose a fraction of F.tularensis water-saline extract saturated 55-60% with ammonium sulfate was split into separate components by preparative methods. One of them, consisting of two antigens of glycoprotein nature, had the capacity of decreasing the digestion of F.tularensis by guinea pig peritoneal macrophages about 10 times. The study revealed that the protein of the preparation obtained in this investigation was capable of suppressing digestion, thus facilitating the active proliferation of F.tularensis inside the cells of the host body.
在本研究中，对土拉弗朗西斯菌抗吞噬因子进行了探寻并尝试对其进行分离。为此，采用制备方法将硫酸铵饱和度为55 - 60%的土拉弗朗西斯菌水盐提取物部分分离成单独的组分。其中之一由两种糖蛋白性质的抗原组成，具有使豚鼠腹膜巨噬细胞对土拉弗朗西斯菌的消化减少约10倍的能力。研究表明，本研究中获得的制剂中的蛋白质能够抑制消化，从而促进土拉弗朗西斯菌在宿主体内细胞中的活跃增殖。
