Meydani S N, Meydani M, Rall L C, Morrow F, Blumberg J B
US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.
Am J Clin Nutr. 1994 Nov;60(5):704-9. doi: 10.1093/ajcn/60.5.704.
The effect of daily supplementation of 800 mg dl alpha-tocopheryl acetate for 30 d on general health, nutrient status, hepatic and renal function, intermediary metabolism, hematological status, plasma nutrients and antioxidant status, thyroid hormones, and urinary creatinine concentrations was studied in 32 healthy elderly (> 60 y) people who participated in a double-blind, placebo-controlled, residential trial. The subjects reported no side effects due to the supplements. Supplementation had no effect on body weight, plasma total protein, albumin, glucose, total cholesterol and triglycerides, conjugated and unconjugated bilirubin, alkaline phosphatase, indicators of hepatic and renal function, hematologic status, thyroid hormones, or serum and urinary creatinine concentrations and creatinine clearance. Supplementation did cause a significant increase in serum vitamin E, and a small (5%) but significant (P < 0.05) increase in plasma zinc in the vitamin E-supplemented group. Thus, short-term supplementation with 800 mg vitamin E/d has no adverse effect on healthy older adults.
在32名健康的老年（>60岁）人群中开展了一项双盲、安慰剂对照的住院试验，研究了连续30天每日补充800毫克dl-α-生育酚醋酸酯对总体健康、营养状况、肝肾功能、中间代谢、血液学状况、血浆营养素和抗氧化状态、甲状腺激素以及尿肌酐浓度的影响。受试者报告称未出现因补充剂导致的副作用。补充剂对体重、血浆总蛋白、白蛋白、葡萄糖、总胆固醇和甘油三酯、结合胆红素和非结合胆红素、碱性磷酸酶、肝肾功能指标、血液学状况、甲状腺激素或血清及尿肌酐浓度以及肌酐清除率均无影响。补充剂确实使维生素E补充组的血清维生素E显著增加，血浆锌小幅（5%）但显著（P<0.05）增加。因此，每日补充800毫克维生素E对健康老年人无不良影响。
