Goh K L, Peh S C, Parasakthi N, Wong N W, Tan K K, Lo Y L
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Am J Gastroenterol. 1994 Oct;89(10):1789-92.
Our objectives were to determine the effect of dual therapy with omeprazole and amoxicillin and of triple therapy with omeprazole, amoxicillin, and metronidazole in the eradication of Helicobacter pylori (HP) and to study the long-term results of eradication in these patients.
A prospective, randomized, controlled trial was performed. Patients who were recruited had unequivocal evidence of HP infection based on culture, histology, rapid urease test, and Gram's stain of a tissue smear. Eradication was defined as the absence of bacteria in all tests performed on both corpus and antral biopsies.
The infection was eradicated in 15 of 19 (78.9%) patients randomized to receive dual therapy and in 19 of 22 (86.4%) patients who received triple therapy. We followed the course of 30 patients in whom HP had been eradicated for a prolonged term (up to 12 months). All remained clear of HP. Twenty-five of 28 patients (89.3%) with duodenal ulcers in whom HP was successfully eradicated remained healed at 12 months. Fewer side effects were reported among patients who received the dual therapy.
Combination therapy with omeprazole and amoxicillin with or without metronidazole is effective in the eradication of HP. In particular, the dual therapy regimen with amoxicillin is not only effective but is also well tolerated by patients.
我们的目的是确定奥美拉唑和阿莫西林联合治疗以及奥美拉唑、阿莫西林和甲硝唑三联治疗对根除幽门螺杆菌（HP）的效果，并研究这些患者根除治疗的长期结果。
进行了一项前瞻性、随机对照试验。招募的患者根据培养、组织学、快速尿素酶试验和组织涂片革兰氏染色有明确的HP感染证据。根除定义为在胃体和胃窦活检的所有检测中均未发现细菌。
随机接受联合治疗的19例患者中有15例（78.9%）感染得到根除，接受三联治疗的22例患者中有19例（86.4%）感染得到根除。我们对30例HP已被根除的患者进行了长期随访（长达12个月）。所有患者HP均未复发。28例十二指肠溃疡患者中有25例（89.3%）HP成功根除，12个月时溃疡仍愈合。接受联合治疗的患者报告的副作用较少。
奥美拉唑与阿莫西林联合使用或联合甲硝唑治疗对根除HP有效。特别是，阿莫西林联合治疗方案不仅有效，而且患者耐受性良好。
