Hu P J, Mitchell H M, Li Y Y, Zhou M H, Hazell S L
First Affiliated Hospital, Sun Yat-Sen University of Medical Science, Guangzhou, China.
Am J Gastroenterol. 1994 Oct;89(10):1806-10.
The aim of the present study was to assess the prevalence of Helicobacter pylori infection in Chinese patients with advanced gastric cancer, to compare this with a matched control population, and to identify factors that may effect the detection of H. pylori in patients with gastric cancer.
Fifty-one patients with advanced gastric cancer and 102 age/sex-matched controls were included in the study. For the detection of H. pylori, both biopsy specimens and sera were collected from the patients, whereas only sera were collected from the controls. A strong association was shown between H. pylori and both intestinal and diffuse type gastric cancer. Antibiotic intake in the month before endoscopic examination, the site of collection of biopsy specimens, and tumor size were identified as factors that may reduce the histological detection of H. pylori in gastric cancer patients.
These data provide supporting evidence of an association between H. pylori infection and gastric cancer and indicate that, in certain circumstances, histological evaluation of H. pylori infection in gastric cancer cases may be less reliable than serological evaluation.
本研究旨在评估中国晚期胃癌患者幽门螺杆菌感染的患病率，与匹配的对照人群进行比较，并确定可能影响胃癌患者幽门螺杆菌检测的因素。
本研究纳入了51例晚期胃癌患者和102例年龄/性别匹配的对照。为检测幽门螺杆菌，从患者中采集活检标本和血清，而对照仅采集血清。幽门螺杆菌与肠型和弥漫型胃癌均显示出强关联。内镜检查前一个月的抗生素摄入、活检标本采集部位和肿瘤大小被确定为可能降低胃癌患者幽门螺杆菌组织学检测的因素。
这些数据为幽门螺杆菌感染与胃癌之间的关联提供了支持性证据，并表明在某些情况下，胃癌病例中幽门螺杆菌感染的组织学评估可能不如血清学评估可靠。
