Iseki K, Tatsuta M, Iishi H, Baba M, Ishiguro S
Department of Gastroenterology, Osaka Medical Centre for Cancer and Cardiovascular Diseases, Japan.
Gut. 1998 Jan;42(1):20-3. doi: 10.1136/gut.42.1.20.
An endoscopic procedure that uses a pH indicator called phenol red to assess Helicobacter pylori infected gastric mucosa has recently been developed. This test makes it possible to take biopsy specimens from H pylori infected areas.
This test was applied to patients with early gastric cancers to clarify the role of H pylori in gastric carcinogenesis.
Sixty five patients with early gastric cancer (50 with differentiated adenocarcinoma and 15 with undifferentiated adenocarcinoma).
Patients with early gastric cancer underwent the endoscopic phenol red test before their operation. In this test, areas infected with H pylori can be observed as "coloured" areas where phenol red was turned from yellow to red.
H pylori infection was significantly (p < 0.001) more frequent in patients with differentiated adenocarcinomas than in those with undifferentiated adenocarcinomas. Differentiated adenocarcinomas were usually located in areas of mucosa infected with H pylori, but undifferentiated adenocarcinomas were frequently located in non-infected areas.
H pylori may be a strong risk factor for differentiated early gastric cancer.
最近开发了一种使用名为酚红的pH指示剂来评估幽门螺杆菌感染胃黏膜的内镜检查方法。该测试使得从幽门螺杆菌感染区域采集活检标本成为可能。
将该测试应用于早期胃癌患者，以阐明幽门螺杆菌在胃癌发生中的作用。
65例早期胃癌患者（50例为分化型腺癌，15例为未分化型腺癌）。
早期胃癌患者在手术前接受内镜酚红测试。在该测试中，幽门螺杆菌感染区域可被观察为酚红从黄色变为红色的“着色”区域。
分化型腺癌患者的幽门螺杆菌感染率显著高于未分化型腺癌患者（p < 0.001）。分化型腺癌通常位于幽门螺杆菌感染的黏膜区域，但未分化型腺癌常位于未感染区域。
幽门螺杆菌可能是分化型早期胃癌的一个重要危险因素。
