Zhang R L, Chayes Z, Korsten M A, Bauman W A
Spinal Cord Damage Research Center, Mount Sinai Medical Center, New York, NY.
Am J Gastroenterol. 1994 Oct;89(10):1856-8.
There is controversy with regard to the effect of spinal cord injury (SCI) on gastric emptying times of liquids. The emptying rates of solids in subjects with SCI have not yet been addressed. Thus, the gastric emptying rates for both liquids and solids were studied by radionuclide imaging in subjects with chronic SCI.
After an overnight fast, subjects with SCI were evaluated for gastric emptying rates for iso-osmolar (normal saline) and hyperosmolar (glucose) liquids and a mixed meal of liquids and solids. Twenty-five subjects received normal saline (500 ml). Of these 25 subjects, 16 and 4 others (a total of 20 subjects) received 75 g glucose dissolved in 225 ml water. Each of the liquid meals was labeled with 300 microCi technetium-99-m-diethylenetriaminepentaacetic acid (99mTc-DPTA). The mixed meal consisted of egg white labeled with 300 microCi technetium-99m-sulfur colloid (99mTc-SC) between two slices of toast with water (110 ml). Each test meal was followed by anterior radionuclide imaging of the stomach with the subject seated. The results were compared with those of matched healthy nonSCI subjects from the literature.
Compared with gastric emptying times reported in the literature in healthy subjects without SCI, no significant differences were noted in those with SCI with regard to rates of gastric emptying for liquids (whether iso- or hyperosmolar) and for solids.
Our findings do not support the previously reported results of a delay in gastric emptying for liquids in subjects with SCI. We have extended our findings of essentially normal rates of gastric emptying of liquids to that of solids.
关于脊髓损伤（SCI）对液体胃排空时间的影响存在争议。SCI患者固体食物的排空率尚未得到研究。因此，我们通过放射性核素成像研究了慢性SCI患者液体和固体食物的胃排空率。
经过一夜禁食后，对SCI患者进行等渗（生理盐水）和高渗（葡萄糖）液体以及液体和固体混合餐的胃排空率评估。25名受试者接受生理盐水（500毫升）。在这25名受试者中，另外16名和4名（共20名受试者）接受溶解于225毫升水中的75克葡萄糖。每餐液体均用300微居里的锝-99m-二乙三胺五乙酸（99mTc-DPTA）标记。混合餐由两片烤面包夹着用300微居里锝-99m-硫胶体（99mTc-SC）标记的蛋清和110毫升水组成。每次测试餐后，让受试者坐着对胃部进行放射性核素前位成像。将结果与文献中匹配的健康非SCI受试者的结果进行比较。
与文献中报道的无SCI健康受试者的胃排空时间相比，SCI患者在液体（无论是等渗还是高渗）和固体食物的胃排空率方面没有显著差异。
我们的研究结果不支持先前报道的SCI患者液体胃排空延迟的结果。我们将液体胃排空率基本正常的研究结果扩展到了固体食物。
