Seiberth V, Linderkamp O, Knorz M C, Liesenhoff H
University Eye Clinic, Klinikum Mannheim, Faculty for Clinical Medicine, University of Heidelberg, Germany.
Am J Ophthalmol. 1994 Oct 15;118(4):492-5. doi: 10.1016/s0002-9394(14)75801-5.
Bright continuous light has been implicated in the pathogenesis of retinopathy of prematurity. To investigate the influence of light on the incidence and severity of retinopathy of prematurity, we enrolled 127 preterm infants (birth weight < or = 1,500 g; gestational age < or = 32 weeks) in a controlled clinical study. Randomization was done separately for three birth-weight groups (< 1,000 g; 1,000 to 1,249 g; 1,250 to 1,500 g). The babies' eyes were patched all day and night from birth to a gestational age of 35 weeks. The infants in the control group were exposed to cycled lighting conditions (that is, reduced light level during the night). Of 62 infants with patched eyes, 26 (42%) developed retinopathy of prematurity. In the control group, 25 of 65 infants (39%) showed retinopathy of prematurity (P = .596). There were also no statistically significant differences in the incidences of retinopathy of prematurity in the birth-weight subgroups or in the severity of retinopathy of prematurity. Thus, patching of the eyes from birth to 35 weeks of postconceptional age does not decrease the risk of retinopathy of prematurity in preterm infants when compared to a control group exposed to cycled lighting conditions.
强光持续照射被认为与早产儿视网膜病变的发病机制有关。为了研究光照对早产儿视网膜病变发生率和严重程度的影响，我们纳入了127例早产儿（出生体重≤1500g；胎龄≤32周）进行一项对照临床研究。对三个出生体重组（<1000g；1000至1249g；1250至1500g）分别进行随机分组。婴儿从出生到孕龄35周期间日夜均佩戴眼罩。对照组婴儿暴露于循环光照条件下（即夜间光照水平降低）。在62例佩戴眼罩的婴儿中，26例（42%）发生了早产儿视网膜病变。在对照组中，65例婴儿中有25例（39%）出现了早产儿视网膜病变（P = 0.596）。在出生体重亚组中早产儿视网膜病变的发生率或早产儿视网膜病变的严重程度也没有统计学上的显著差异。因此，与暴露于循环光照条件的对照组相比，从出生到孕龄35周期间佩戴眼罩并不能降低早产儿发生早产儿视网膜病变的风险。
