Kennedy K A, Ipson M A, Birch D G, Tyson J E, Anderson J L, Nusinowitz S, West L, Spencer R, Birch E E
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas 75235, USA.
Arch Dis Child Fetal Neonatal Ed. 1997 May;76(3):F168-73. doi: 10.1136/fn.76.3.f168.
To examine the effects of light on retinal development and function in preterm infants as measured by the electroretinogram (ERG). Secondary outcomes included visual acuity testing, the incidence of retinopathy of prematurity, and general wellbeing, reflected in feeding tolerance, rate of weight gain, and length of hospital stay.
Eligibility criteria for enrollment were birthweight < or = 1250 g and gestational age < or = 31 weeks. Sixty one infants were randomly allocated by 6 hours after birth to a control or treatment group which wore 97% light filtering goggles for a minimum of four weeks or until the infant reached 31 weeks postmenstrual age.
There were no significant differences between the two groups in the numbers of electroretinograms performed at 36 weeks of postmenstrual age. Although the sample size was not large enough to exclude clinically important differences in secondary outcomes, no significant differences were observed between the groups in visual acuity testing at 4-6 months corrected age, incidence of retinopathy of prematurity, weight gain, or length of stay.
These data support the safety and feasibility of this intervention. A much larger study will be needed to determine whether light reduction to the eyes of very low birthweight infants will reduce the incidence of retinopathy of prematurity or enhance general well-being.
通过视网膜电图（ERG）检测，研究光线对早产儿视网膜发育和功能的影响。次要结果包括视力测试、早产儿视网膜病变的发生率以及反映在喂养耐受性、体重增加率和住院时间上的总体健康状况。
纳入标准为出生体重≤1250g且胎龄≤31周。61名婴儿在出生后6小时内被随机分配至对照组或治疗组，治疗组佩戴97%滤光护目镜至少四周或直至婴儿达到孕龄31周。
在孕龄36周时进行的视网膜电图检查次数，两组之间无显著差异。虽然样本量不足以排除次要结果中具有临床意义的差异，但在矫正年龄4 - 6个月时的视力测试、早产儿视网膜病变的发生率、体重增加或住院时间方面，两组之间未观察到显著差异。
这些数据支持了该干预措施的安全性和可行性。需要进行更大规模的研究，以确定减少极低出生体重儿眼睛的光照是否会降低早产儿视网膜病变的发生率或改善总体健康状况。
