McLeod D R, Foster G V, Hoehn-Saric R, Svikis D S, Hipsley P A
Department of Psychiatry, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21287-7144.
Alcohol Clin Exp Res. 1994 Jun;18(3):664-70. doi: 10.1111/j.1530-0277.1994.tb00928.x.
This study sought to determine whether family history of alcoholism is related to patient reports of premenstrual alcohol consumption and whether family history of alcoholism is related to severity of anxiety-related symptoms, in women who suffer simultaneously from both premenstrual syndrome and generalized anxiety disorder. Fifty-four women with generalized anxiety disorder and prospectively demonstrated premenstrual syndrome were questioned about family history of alcoholism and alcohol consumption patterns across the menstrual cycle. Seventy-six percent of the sample reported having an alcoholic first- or second-degree relative. Furthermore, 74% of those women having a paternal-side family history of alcoholism, but only 22% of those without such a family history, reported increased alcohol consumption premenstrually. Forty-one of these women were assessed by means of psychiatric rating scales during both the premenstrual and follicular phases of the menstrual cycle. During the premenstrual, but not the follicular, phase of the menstrual cycle, women with a paternal-side family history of alcoholism experienced more severe anxiety-related somatic, but not psychic, symptoms of anxiety, than those without such a family history. These findings suggest that family history of alcoholism may be related to premenstrual alcohol consumption patterns and to the severity of premenstrually experienced somatic symptoms of anxiety in women with premenstrual syndrome, and that these women may be self-medicating with alcohol.
本研究旨在确定，对于同时患有经前综合征和广泛性焦虑症的女性，酗酒家族史是否与患者经前饮酒的报告有关，以及酗酒家族史是否与焦虑相关症状的严重程度有关。对54名患有广泛性焦虑症且前瞻性地表现出经前综合征的女性，询问了她们的酗酒家族史以及整个月经周期的饮酒模式。76%的样本报告有酗酒的一级或二级亲属。此外，有父系家族酗酒史的女性中，74%报告经前饮酒量增加，而无此类家族史的女性中只有22%报告经前饮酒量增加。在月经周期的经前期和卵泡期，通过精神科评定量表对其中41名女性进行了评估。在月经周期的经前期而非卵泡期，有父系家族酗酒史的女性比无此类家族史的女性经历了更严重的焦虑相关躯体症状（而非精神症状）。这些发现表明，酗酒家族史可能与经前饮酒模式以及经前综合征女性经前经历的焦虑躯体症状的严重程度有关，并且这些女性可能用酒精进行自我治疗。
