[Pharmacokinetics and pharmacodynamics of thiopental sodium in pregnant women during cesarean section].

Comparative study of thiopental pharmacokinetics and hemodynamics has been conducted in two groups of pregnant women subjected to planned cesarean section. Group I consisted of 6 women (thiopental dose 8.0 mg/kg was combined with components of neuroleptanalgesia), group II consisted of 7 women (the drug dose 4.68 mg/kg was combined with moradol analgesia). Dose-dependent differences in pharmacokinetic regularities of sodium thiopental in the groups compared have been revealed. Moradol did not cause the drug accumulation in the bodies of mother and fetus. The higher Apgar score was characteristic of the newborns from group II. Adequate anesthesia in pregnant women from group II was due to the potentiating effect of moradol. In both groups a correlation has been established between pharmacokinetic parameters and hemodynamic changes, as well as between sodium thiopental concentration in maternal and umbilical blood and pharmacokinetic parameters.