Sariev A K, Proshina I V, Folomeeva I Iu, Zerdev V P
Anesteziol Reanimatol. 1993 Mar-Apr(2):46-50.
Comparative study of thiopental pharmacokinetics and hemodynamics has been conducted in two groups of pregnant women subjected to planned cesarean section. Group I consisted of 6 women (thiopental dose 8.0 mg/kg was combined with components of neuroleptanalgesia), group II consisted of 7 women (the drug dose 4.68 mg/kg was combined with moradol analgesia). Dose-dependent differences in pharmacokinetic regularities of sodium thiopental in the groups compared have been revealed. Moradol did not cause the drug accumulation in the bodies of mother and fetus. The higher Apgar score was characteristic of the newborns from group II. Adequate anesthesia in pregnant women from group II was due to the potentiating effect of moradol. In both groups a correlation has been established between pharmacokinetic parameters and hemodynamic changes, as well as between sodium thiopental concentration in maternal and umbilical blood and pharmacokinetic parameters.
对两组计划剖宫产的孕妇进行了硫喷妥钠药代动力学和血流动力学的比较研究。第一组由6名女性组成（硫喷妥钠剂量8.0mg/kg与神经安定镇痛合剂成分合用），第二组由7名女性组成（药物剂量4.68mg/kg与吗啡镇痛合用）。已揭示出所比较的两组中硫喷妥钠药代动力学规律的剂量依赖性差异。吗啡未导致药物在母体和胎儿体内蓄积。第二组新生儿的阿氏评分较高。第二组孕妇的充分麻醉归因于吗啡的增效作用。在两组中，已确立了药代动力学参数与血流动力学变化之间的相关性，以及母体血和脐血中硫喷妥钠浓度与药代动力学参数之间的相关性。
