Christensen J H, Andreasen F, Jansen J A
Acta Anaesthesiol Scand. 1981 Apr;25(2):174-9. doi: 10.1111/j.1399-6576.1981.tb01632.x.
Anaesthesia for planned caesarian section in nine women was induced with an i.v. thiopental injection. The injection was stopped when the ciliary reflex disappeared. 250-300 mg was given over 60-85 seconds. The concentration of thiopental in peripheral venous blood 20 s after the disappearance of the ciliary reflex varied from 4.3 to 33.7 micrograms/ml. The simultaneously obtained concentrations at delivery (11-25 min after the start of the induction) were 1.7-6.0 micrograms/ml in venous blood from the mothers and 1.3-5.5 micrograms/ml in cord vein blood. In two of the newborns, the Apgar scores were 8 and 9, in the other seven it was 10. The baby with Apgar score 8 was delivered after 25 min and had a concentration in cord vein blood of 3.5 micrograms/ml. The decline in the concentration of thiopental in the venous blood of the mothers was described by a three-compartment open model. The terminal half-life was relatively short, between 91 and 595 min. The blood levels of thiopental in the newborns were followed for 22-33 h. The terminal half-lives in the babies ranged from 616 to 2560 min.
9名孕妇计划剖宫产的麻醉通过静脉注射硫喷妥钠诱导。当睫状反射消失时停止注射。在60 - 85秒内给予250 - 300毫克。睫状反射消失后20秒外周静脉血中硫喷妥钠的浓度在4.3至33.7微克/毫升之间。分娩时（诱导开始后11 - 25分钟）同时测得的浓度，母亲静脉血中为1.7 - 6.0微克/毫升，脐静脉血中为1.3 - 5.5微克/毫升。两名新生儿的阿氏评分分别为8分和9分，其他七名新生儿的阿氏评分为10分。阿氏评分为8分的婴儿在25分钟后娩出，脐静脉血浓度为3.5微克/毫升。母亲静脉血中硫喷妥钠浓度的下降情况用三室开放模型描述。终末半衰期相对较短，在91至595分钟之间。对新生儿的硫喷妥钠血药浓度进行了22 - 33小时的监测。婴儿的终末半衰期在616至2560分钟之间。
