Barton J J, Huaman A G, Sharpe J A
Neuro-ophthalmology Unit, Toronto Hospital Neurological Center, Ontario, Canada.
Ann Neurol. 1994 Oct;36(4):585-94. doi: 10.1002/ana.410360407.
We measured saccadic peak velocities in 8 patients with myasthenia gravis, 9 patients with proven nonmyasthenic ocular palsies, and 3 controls. Patients followed a target moving to and from primary position at 1-second intervals for 8 minutes. We measured the amplitudes and velocities of centrifugal saccades at the start of the task, after 3 minutes of the task (fatigue) and 1 minute after receiving IV edrophonium. The effects of fatigue, though prominent in some myasthenic patients, did not distinguish between the groups. However, edrophonium increased saccadic peak velocities in myasthenic patients but decreased them in both controls and nonmyasthenic patients. Analysis of saccades by amplitude bins showed that these changes in peak velocity reflected shifts in the velocity-amplitude relationship.
我们测量了8例重症肌无力患者、9例已证实为非重症肌无力性眼肌麻痹患者和3例对照组的扫视峰值速度。患者跟随一个目标以1秒的间隔在初始位置来回移动8分钟。我们在任务开始时、任务进行3分钟（疲劳）后以及静脉注射依酚氯铵1分钟后测量离心扫视的幅度和速度。疲劳的影响虽然在一些重症肌无力患者中很明显，但并未区分不同组。然而，依酚氯铵增加了重症肌无力患者的扫视峰值速度，但在对照组和非重症肌无力患者中均降低了扫视峰值速度。按幅度区间对扫视进行分析表明，峰值速度的这些变化反映了速度-幅度关系的变化。
